Ontology highlight
ABSTRACT:
SUBMITTER: Hideaki Tsuge
PROVIDER: EMPIAR-11235 | biostudies-other |
REPOSITORIES: biostudies-other
Nature communications 20221017 1
Some bacteria express a binary toxin translocation system, consisting of an enzymatic subunit and translocation pore, that delivers enzymes into host cells through endocytosis. The most clinically important bacterium with such a system is Clostridioides difficile (formerly Clostridium). The CDTa and CDTb proteins from its system represent important therapeutic targets. CDTb has been proposed to be a di-heptamer, but its physiological heptameric structure has not yet been reported. Here, we repor ...[more]