Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide
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ABSTRACT:
SUBMITTER: C Axel Innis
PROVIDER: EMPIAR-11241 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs.
Leroy Elodie C EC Perry Thomas N TN Renault Thibaud T TT Innis C Axel CA
Nature chemical biology 20230615 9
As antimicrobial resistance threatens our ability to treat common bacterial infections, new antibiotics with limited cross-resistance are urgently needed. In this regard, natural products that target the bacterial ribosome have the potential to be developed into potent drugs through structure-guided design, provided their mechanisms of action are well understood. Here we use inverse toeprinting coupled to next-generation sequencing to show that the aromatic polyketide tetracenomycin X primarily ...[more]
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