Amyloid fibril from the antimicrobial peptide aurein 3.3
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ABSTRACT:
SUBMITTER: Robert Bücker
PROVIDER: EMPIAR-11270 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils.
Bücker Robert R Seuring Carolin C Cazey Cornelia C Veith Katharina K García-Alai Maria M Grünewald Kay K Landau Meytal M
Nature communications 20220727 1
The amyloid-antimicrobial link hypothesis is based on antimicrobial properties found in human amyloids involved in neurodegenerative and systemic diseases, along with amyloidal structural properties found in antimicrobial peptides (AMPs). Supporting this hypothesis, we here determined the fibril structure of two AMPs from amphibians, uperin 3.5 and aurein 3.3, by cryogenic electron microscopy (cryo-EM), revealing amyloid cross-β fibrils of mated β-sheets at atomic resolution. Uperin 3.5 formed a ...[more]
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| S-EPMC2765228 | biostudies-literature
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