Ontology highlight
ABSTRACT:
SUBMITTER: Tsung-Han Chou
PROVIDER: EMPIAR-11279 | biostudies-other |
REPOSITORIES: biostudies-other
Chou Tsung-Han TH Epstein Max M Michalski Kevin K Fine Eve E Biggin Philip C PC Furukawa Hiro H
Nature structural & molecular biology 20220530 6
Excitatory signaling mediated by N-methyl-D-aspartate receptor (NMDAR) is critical for brain development and function, as well as for neurological diseases and disorders. Channel blockers of NMDARs are of medical interest owing to their potential for treating depression, Alzheimer's disease, and epilepsy. However, precise mechanisms underlying binding and channel blockade have remained limited owing to challenges in obtaining high-resolution structures at the binding site within the transmembran ...[more]