Unknown

Dataset Information

0

Cryo-EM SPA dataset for Antibody SKV09 in complex with VEEV VLP (K3 movies/.tif files)


ABSTRACT:

SUBMITTER: Ryan Gavin Casner 

PROVIDER: EMPIAR-11338 | biostudies-other |

REPOSITORIES: biostudies-other

altmetric image

Publications


Alphaviruses are RNA viruses that represent emerging public health threats. To identify protective antibodies, we immunized macaques with a mixture of western, eastern, and Venezuelan equine encephalitis virus-like particles (VLPs), a regimen that protects against aerosol challenge with all three viruses. Single- and triple-virus-specific antibodies were isolated, and we identified 21 unique binding groups. Cryo-EM structures revealed that broad VLP binding inversely correlated with sequence and  ...[more]

Similar Datasets

| EMPIAR-11249 | biostudies-other
| EMPIAR-11250 | biostudies-other
| EMPIAR-11527 | biostudies-other
| EMPIAR-11662 | biostudies-other
| S-EPMC7035235 | biostudies-literature