Ontology highlight
ABSTRACT:
SUBMITTER: Ryan Gavin Casner
PROVIDER: EMPIAR-11338 | biostudies-other |
REPOSITORIES: biostudies-other
Cell 20230608 12
Alphaviruses are RNA viruses that represent emerging public health threats. To identify protective antibodies, we immunized macaques with a mixture of western, eastern, and Venezuelan equine encephalitis virus-like particles (VLPs), a regimen that protects against aerosol challenge with all three viruses. Single- and triple-virus-specific antibodies were isolated, and we identified 21 unique binding groups. Cryo-EM structures revealed that broad VLP binding inversely correlated with sequence and ...[more]