Cryo electron microscopy of Mce1 transporter from Mycobacterium smegmatis
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ABSTRACT:
SUBMITTER: James Chen
PROVIDER: EMPIAR-11343 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of an endogenous mycobacterial MCE lipid transporter.
Chen James J Fruhauf Alice A Fan Catherine C Ponce Jackeline J Ueberheide Beatrix B Bhabha Gira G Ekiert Damian C DC
Nature 20230726 7973
To replicate inside macrophages and cause tuberculosis, Mycobacterium tuberculosis must scavenge a variety of nutrients from the host<sup>1,2</sup>. The mammalian cell entry (MCE) proteins are important virulence factors in M. tuberculosis<sup>1,3</sup>, where they are encoded by large gene clusters and have been implicated in the transport of fatty acids<sup>4-7</sup> and cholesterol<sup>1,4,8</sup> across the impermeable mycobacterial cell envelope. Very little is known about how cargos are tr ...[more]
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