Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis
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ABSTRACT:
SUBMITTER: K C Garcia
PROVIDER: EMPIAR-11346 | biostudies-other |
REPOSITORIES: biostudies-other
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Organizing structural principles of the IL-17 ligand-receptor axis.
Wilson Steven C SC Caveney Nathanael A NA Yen Michelle M Pollmann Christoph C Xiang Xinyu X Jude Kevin M KM Hafer Maximillian M Tsutsumi Naotaka N Piehler Jacob J Garcia K Christopher KC
Nature 20220721 7927
The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases<sup>1</sup>. The compositions and structures of functional IL-17 family ligand-receptor signalling assemblies remain unclear. IL-17E (also known as IL-25) is a key regulator of type 2 immune responses and driver of inflammatory diseases, such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functional responses<sup>2</sup> ...[more]
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