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Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist

ABSTRACT:

SUBMITTER: Osamu Nureki

PROVIDER: EMPIAR-11350 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.

Akasaka Hiroaki H Tanaka Tatsuki T Sano Fumiya K FK Matsuzaki Yuma Y Shihoya Wataru W Nureki Osamu O

Nature communications 20220915 1

Lysophosphatidic acid receptor 1 (LPA1) is one of the six G protein-coupled receptors activated by the bioactive lipid, lysophosphatidic acid (LPA). LPA1 is a drug target for various diseases, including cancer, inflammation, and neuropathic pain. Notably, LPA1 agonists have potential therapeutic value for obesity and urinary incontinence. Here, we report a cryo-electron microscopy structure of the active human LPA1-Gi complex bound to ONO-07 ...[more]

PMID: 36109516

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Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.

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