Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism
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ABSTRACT:
SUBMITTER: Christopher G Bunick
PROVIDER: EMPIAR-11362 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Lomakin Ivan B IB Devarkar Swapnil C SC Patel Shivali S Grada Ayman A Bunick Christopher G CG
Nucleic acids research 20230401 6
Acne vulgaris is a chronic disfiguring skin disease affecting ∼1 billion people worldwide, often having persistent negative effects on physical and mental health. The Gram-positive anaerobe, Cutibacterium acnes is implicated in acne pathogenesis and is, therefore, a main target for antibiotic-based acne therapy. We determined a 2.8-Å resolution structure of the 70S ribosome of Cutibacterium acnes by cryogenic electron microscopy and discovered that sarecycline, a narrow-spectrum antibiotic again ...[more]
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