Dataset Information
ChRmine in MSP1E3D1 lipid nanodisc
Ontology highlight
ABSTRACT:
SUBMITTER: Stephen Brohawn
PROVIDER: EMPIAR-11376 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs.
Nature communications 20220817 1
Microbial channelrhodopsins are light-gated ion channels widely used for optogenetic manipulation of neuronal activity. ChRmine is a bacteriorhodopsin-like cation channelrhodopsin (BCCR) more closely related to ion pump rhodopsins than other channelrhodopsins. ChRmine displays unique properties favorable for optogenetics including high light sensitivity, a broad, red-shifted activation spectrum, cation selectivity, and large photocurrents, while its slow closing kinetics impedes some application ...[more]