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Cryogenic electron tomographs of Coxsackievirus A9


ABSTRACT:

SUBMITTER: Sarah Jane Butcher 

PROVIDER: EMPIAR-11386 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural Studies Reveal that Endosomal Cations Promote Formation of Infectious Coxsackievirus A9 A-Particles, Facilitating RNA and VP4 Release.

Domanska Aušra A   Plavec Zlatka Z   Ruokolainen Visa V   Löflund Benita B   Marjomäki Varpu V   Butcher Sarah J SJ  

Journal of virology 20221130 24


Coxsackievirus A9 (CVA9), an enterovirus, is a common cause of pediatric aseptic meningitis and neonatal sepsis. During cell entry, enterovirus capsids undergo conformational changes leading to expansion, formation of large pores, externalization of VP1 N termini, and loss of the lipid factor from VP1. Factors such as receptor binding, heat, and acidic pH can trigger capsid expansion in some enteroviruses. Here, we show that fatty acid-free bovine serum albumin or neutral endosomal ionic conditi  ...[more]

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