Unknown

Dataset Information

0

PKA-phosphorylated CPVT variant human ryanodine receptor type 2 R2474S in the presence of Rycal ARM210 - RyR2-R2474S + ARM210

ABSTRACT:

SUBMITTER: Marco Cesar Miotto 

PROVIDER: EMPIAR-11402 | biostudies-other |

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.

Miotto Marco C MC   Weninger Gunnar G   Dridi Haikel H   Yuan Qi Q   Liu Yang Y   Wronska Anetta A   Melville Zephan Z   Sittenfeld Leah L   Reiken Steven S   Marks Andrew R AR  

Science advances 20220720 29

Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT results from stress-induced sarcoplasmic reticular Ca<sup>2+</sup> leak via the mutant RyR2 channels during diastole. We present atomic models of human wild-type (WT) RyR2 and the CPVT mutant RyR2-R2474S determined by cryo-electron microscopy with overall resolutions in the range of 2.6 to 3.6 Å, and re  ...[more]

Similar Datasets

Unknown PKA-phosphorylated CPVT variant human ryanodine receptor type 2 R2474S - RyR2-R2474S
| EMPIAR-11401 | biostudies-other
Unknown PKA-phosphorylated human ryanodine receptor type 2 RyR2
| EMPIAR-11395 | biostudies-other
Unknown PKA-phosphorylated CPVT variant human ryanodine receptor type 2 R2474S in the presence of calmodulin - RyR2-R2474S + CaM
| EMPIAR-11403 | biostudies-other
Unknown PKA-phosphorylated human ryanodine receptor type 2 in the presence of calmodulin - RyR2 + CaM
| EMPIAR-11396 | biostudies-other
Unknown dephosphorylated human ryanodine receptor type 2 RyR2
| EMPIAR-11391 | biostudies-other
Unknown Molecular Dynamics Simulations of the Cardiac Ryanodine Receptor Type 2 (RyR2) Gating Mechanism.
| S-EPMC9720719 | biostudies-literature
Unknown Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutations.
| S-EPMC4392826 | biostudies-literature
Unknown Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.
| S-EPMC1218255 | biostudies-other
Unknown PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity.
| S-EPMC3674825 | biostudies-literature
Unknown Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions.
| S-EPMC4281514 | biostudies-literature