Dataset Information
PKA-phosphorylated CPVT variant human ryanodine receptor type 2 R2474S in the presence of Rycal ARM210 - RyR2-R2474S + ARM210
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ABSTRACT:
SUBMITTER: Marco Cesar Miotto
PROVIDER: EMPIAR-11402 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Science advances 20220720 29
Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT results from stress-induced sarcoplasmic reticular Ca<sup>2+</sup> leak via the mutant RyR2 channels during diastole. We present atomic models of human wild-type (WT) RyR2 and the CPVT mutant RyR2-R2474S determined by cryo-electron microscopy with overall resolutions in the range of 2.6 to 3.6 Å, and re ...[more]