Cryo-EM structure of the human Sirtuin 6-nucleosome complex
Ontology highlight
ABSTRACT:
SUBMITTER: Jean-Paul Armache
PROVIDER: EMPIAR-11427 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Chio Un Seng US Rechiche Othman O Bryll Alysia R AR Zhu Jiang J Leith Erik M EM Feldman Jessica L JL Peterson Craig L CL Tan Song S Armache Jean-Paul JP
Science advances 20230414 15
Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 removes acetyl groups from histone H3 in nucleosomes, but the molecular basis for its nucleosomal substrate preference is unknown. Our cryo-electron microscopy structure of human SIRT6 in complex with the nucleosome shows that the catalytic domain of SIRT6 pries DNA from the nucleosomal entry-exit site and exposes the histo ...[more]
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