Dataset Information
Cryo-EM structure of the human Sirtuin 6-nucleosome complex
Ontology highlight
ABSTRACT:
SUBMITTER: Jean-Paul Armache
PROVIDER: EMPIAR-11427 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Science advances 20230414 15
Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 removes acetyl groups from histone H3 in nucleosomes, but the molecular basis for its nucleosomal substrate preference is unknown. Our cryo-electron microscopy structure of human SIRT6 in complex with the nucleosome shows that the catalytic domain of SIRT6 pries DNA from the nucleosomal entry-exit site and exposes the histo ...[more]
