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LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer

ABSTRACT:

SUBMITTER: Ximena Barros-Álvarez

PROVIDER: EMPIAR-11432 | biostudies-other |

REPOSITORIES: biostudies-other

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The tethered peptide activation mechanism of adhesion GPCRs.

Barros-Álvarez Ximena X Nwokonko Robert M RM Vizurraga Alexander A Matzov Donna D He Feng F Papasergi-Scott Makaía M MM Robertson Michael J MJ Panova Ouliana O Yardeni Eliane Hadas EH Seven Alpay B AB Kwarcinski Frank E FE Su Hongyu H Peroto Maria Claudia MC Meyerowitz Justin G JG Shalev-Benami Moran M Tall Gregory G GG Skiniotis Georgios G

Nature 20220413 7907

Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions<sup>1</sup>. Self cleavage within the aGPCR auto-proteolysis-inducing (GAIN) domain produces two protomers-N-terminal and C-terminal fragments-that remain non-covalently attached after receptors reach the cell surface<sup>1</sup>. Upon dissociation of the N-terminal fragment, the C-terminus of the GAIN ...[more]

PMID: 35418682

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