Structure of the Nucleosome Core Particle from Trypanosoma brucei
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ABSTRACT:
SUBMITTER: Marcus David wilson
PROVIDER: EMPIAR-11454 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Histone divergence in trypanosomes results in unique alterations to nucleosome structure.
Deák Gauri G Wapenaar Hannah H Sandoval Gorka G Chen Ruofan R Taylor Mark R D MRD Burdett Hayden H Watson James A JA Tuijtel Maarten W MW Webb Shaun S Wilson Marcus D MD
Nucleic acids research 20230801 15
Eukaryotes have a multitude of diverse mechanisms for organising and using their genomes, but the histones that make up chromatin are highly conserved. Unusually, histones from kinetoplastids are highly divergent. The structural and functional consequences of this variation are unknown. Here, we have biochemically and structurally characterised nucleosome core particles (NCPs) from the kinetoplastid parasite Trypanosoma brucei. A structure of the T. brucei NCP reveals that global histone archite ...[more]
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