Dataset Information
Cryo-EM micrographs for the Bombyx mori R2 retrotransposon initiating target-primed reverse transcription
Ontology highlight
ABSTRACT:
SUBMITTER: Max Wilkinson
PROVIDER: EMPIAR-11458 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription.
Science (New York, N.Y.) 20230406 6642
Non-long terminal repeat (non-LTR) retrotransposons, or long interspersed nuclear elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes by target-primed reverse transcription (TPRT). During TPRT, a target DNA sequence is nicked and primes reverse transcription of the retrotransposon RNA. Here, we report the cryo-electron microscopy structure of the <i>Bombyx mori</i> R2 non-LTR retrotransposon initiating TPRT at its ribosomal DNA target. The target DNA sequen ...[more]