Dataset Information
Electron cryo-tomography data on the ER-mitochondria encounter structure in cryo-FIB milled yeast cells
Ontology highlight
ABSTRACT:
SUBMITTER: Wanda Kukulski
PROVIDER: EMPIAR-11462 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
In situ architecture of the ER-mitochondria encounter structure.
Nature 20230510 7963
The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane biogenesis that rely on lipid exchange via membrane contact sites<sup>1-3</sup>, but the underpinning mechanisms remain poorly understood. In yeast, tethering and lipid transfer between the two organelles is mediated by the endoplasmic reticulum-mitochondria encounter structure (ERMES), a four-subunit complex of unresolved stoichiometry and architecture<sup>4-6</sup>. Here we determined the molecular organization of ...[more]