Dataset Information
Single particle cryoEM of cannabinoid receptor 1/G protein complex bound to an endocannabinoid analogue
Ontology highlight
ABSTRACT:
SUBMITTER: Michael Robertson
PROVIDER: EMPIAR-11474 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for activation of CB1 by an endocannabinoid analog.
Nature communications 20230509 1
Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses. Hence, understanding the structural and functional consequences of eCB-CB1 interactions has important implications for designing effective drugs targeting this receptor. To characterize the molecular details of eCB interaction with CB1, we utilized AMG315, an analog of the eCB anandamide to determine the stru ...[more]