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Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2

ABSTRACT:

SUBMITTER: Axel T Brunger

PROVIDER: EMPIAR-11475 | biostudies-other |

REPOSITORIES: biostudies-other

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.

Yang Kailu K Wang Chuchu C Kreutzberger Alex J B AJB Ojha Ravi R Kuivanen Suvi S Couoh-Cardel Sergio S Muratcioglu Serena S Eisen Timothy J TJ White K Ian KI Held Richard G RG Subramanian Subu S Marcus Kendra K Pfuetzner Richard A RA Esquivies Luis L Doyle Catherine A CA Kuriyan John J Vapalahti Olli O Balistreri Giuseppe G Kirchhausen Tom T Brunger Axel T AT

Proceedings of the National Academy of Sciences of the United States of America 20220919 40

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, there is a specific urgent need for alternative antivirals that target processes less likely to be affected by mutation, such as the membrane fusion step of viral entry into the host cell. One such antiviral class includes peptide inhi ...[more]

PMID: 36122200

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