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Human dimeric alpha-catenin binding to F-actin

ABSTRACT:

SUBMITTER: Rangarajan Srinivasan Erumbi

PROVIDER: EMPIAR-11479 | biostudies-other |

REPOSITORIES: biostudies-other

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Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments.

Rangarajan Erumbi S ES Smith Emmanuel W EW Izard Tina T

Communications biology 20230316 1

Attachment between cells is crucial for almost all aspects of the life of cells. These inter-cell adhesions are mediated by the binding of transmembrane cadherin receptors of one cell to cadherins of a neighboring cell. Inside the cell, cadherin binds β-catenin, which interacts with α-catenin. The transitioning of cells between migration and adhesion is modulated by α-catenin, which links cell junctions and the plasma membrane to the actin cytoskeleton. At cell junctions, a single β-catenin/α-ca ...[more]

PMID: 36928388

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