Dataset Information
Cryo-EM structure of human tRNA(GlyCCC) - PUS4 and PUS7 modified
Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian Glatt
PROVIDER: EMPIAR-11517 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Determining the effects of pseudouridine incorporation on human tRNAs.
The EMBO journal 20250429 13
Transfer RNAs (tRNAs) are ubiquitous non-coding RNA molecules required to translate mRNA-encoded sequence information into nascent polypeptide chains. Their relatively small size and heterogenous patterns of their RNA modifications have impeded the systematic structural characterization of individual tRNAs. Here, we use single-particle cryo-EM to determine the structures of four human tRNAs before and after incorporation of pseudouridines (Ψ). Following post-transcriptional modifications by dist ...[more]