Dataset Information
Single particle cryo-EM dataset of Mus musculus mitochondrial complex I bound with inhibitor Piericidin A
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-11530 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I.
Science advances 20230802 31
Respiratory complex I, a key enzyme in mammalian metabolism, captures the energy released by reduction of ubiquinone by NADH to drive protons across the inner mitochondrial membrane, generating the proton-motive force for ATP synthesis. Despite remarkable advances in structural knowledge of this complicated membrane-bound enzyme, its mechanism of catalysis remains controversial. In particular, how ubiquinone reduction is coupled to proton pumping and the pathways and mechanisms of proton translo ...[more]