Human Teneurin-2 and human Latrophilin-3 binary complex
Ontology highlight
ABSTRACT:
SUBMITTER: Demet Araç
PROVIDER: EMPIAR-11609 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Li Jingxian J Xie Yuan Y Cornelius Shaleeka S Jiang Xian X Sando Richard R Kordon Szymon P SP Pan Man M Leon Katherine K Südhof Thomas C TC Zhao Minglei M Araç Demet D
Nature communications 20200501 1
The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs/ADGRLs) promotes excitatory synapse formation when LPHNs simultaneously interact with FLRTs. Insertion of a short alternatively-spliced region within TENs abolishes the TEN-LPHN interaction and switches TEN function to specify inhibitory synapses. How alternative-splicing regulates TEN-LPHN interaction remains unclear. Here, we report the 2.9 Å resolution cryo-EM structure of the TEN2-LPHN3 co ...[more]
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