Dataset Information
CryoEM micrographs of HK97 small terminase in complex with DNA (2 datasets:550 and 1874 multi-frame micrographs composed of 50 frames in tif format)
Ontology highlight
ABSTRACT:
SUBMITTER: Alfred A. Antson
PROVIDER: EMPIAR-11620 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for DNA recognition by a viral genome-packaging machine.
Proceedings of the National Academy of Sciences of the United States of America 20240808 33
DNA recognition is critical for assembly of double-stranded DNA viruses, particularly for the initiation of packaging the viral genome into the capsid. The key component that recognizes viral DNA is the small terminase protein. Despite prior studies, the molecular mechanism for DNA recognition remained elusive. Here, we address this question by identifying the minimal site in the bacteriophage HK97 genome specifically recognized by the small terminase and determining the structure of this comple ...[more]