Cryo-EM structure of ERGIC-53 H34 deletion mutant in complex with MCFD2
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ABSTRACT:
SUBMITTER: Satoshi Watanabe
PROVIDER: EMPIAR-11645 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport.
Watanabe Satoshi S Kise Yoshiaki Y Yonezawa Kento K Inoue Mariko M Shimizu Nobutaka N Nureki Osamu O Inaba Kenji K
Nature communications 20240316 1
ERGIC-53 transports certain subsets of newly synthesized secretory proteins and membrane proteins from the endoplasmic reticulum to the Golgi apparatus. Despite numerous structural and functional studies since its identification, the overall architecture and mechanism of action of ERGIC-53 remain unclear. Here we present cryo-EM structures of full-length ERGIC-53 in complex with its functional partner MCFD2. These structures reveal that ERGIC-53 exists as a homotetramer, not a homohexamer as pre ...[more]
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