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Cryo-EM micrographs of RESC1-RESC2 complex bound to gRNA

ABSTRACT:

SUBMITTER: Luciano Graciani Dolce

PROVIDER: EMPIAR-11677 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural basis for guide RNA selection by the RESC1-RESC2 complex.

Dolce Luciano G LG Nesterenko Yevheniia Y Walther Leon L Weis Félix F Kowalinski Eva E

Nucleic acids research 20230501 9

Kinetoplastid parasites, such as trypanosomes or leishmania, rely on RNA-templated RNA editing to mature mitochondrial cryptic pre-mRNAs into functional protein-coding transcripts. Processive pan-editing of multiple editing blocks within a single transcript is dependent on the 20-subunit RNA editing substrate binding complex (RESC) that serves as a platform to orchestrate the interactions between pre-mRNA, guide RNAs (gRNAs), the catalytic RNA editing complex (RECC), and a set of RNA helicases. ...[more]

PMID: 36999600

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