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Cryo-EM micrographs of RESC1-RESC2 complex bound to gRNA


ABSTRACT:

SUBMITTER: Luciano Graciani Dolce 

PROVIDER: EMPIAR-11677 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structural basis for guide RNA selection by the RESC1-RESC2 complex.

Dolce Luciano G LG   Nesterenko Yevheniia Y   Walther Leon L   Weis Félix F   Kowalinski Eva E  

Nucleic acids research 20230501 9


Kinetoplastid parasites, such as trypanosomes or leishmania, rely on RNA-templated RNA editing to mature mitochondrial cryptic pre-mRNAs into functional protein-coding transcripts. Processive pan-editing of multiple editing blocks within a single transcript is dependent on the 20-subunit RNA editing substrate binding complex (RESC) that serves as a platform to orchestrate the interactions between pre-mRNA, guide RNAs (gRNAs), the catalytic RNA editing complex (RECC), and a set of RNA helicases.  ...[more]

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