Cryo-EM micrographs of RESC1-RESC2 complex bound to gRNA
Ontology highlight
ABSTRACT:
SUBMITTER: Luciano Graciani Dolce
PROVIDER: EMPIAR-11677 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for guide RNA selection by the RESC1-RESC2 complex.
Dolce Luciano G LG Nesterenko Yevheniia Y Walther Leon L Weis Félix F Kowalinski Eva E
Nucleic acids research 20230501 9
Kinetoplastid parasites, such as trypanosomes or leishmania, rely on RNA-templated RNA editing to mature mitochondrial cryptic pre-mRNAs into functional protein-coding transcripts. Processive pan-editing of multiple editing blocks within a single transcript is dependent on the 20-subunit RNA editing substrate binding complex (RESC) that serves as a platform to orchestrate the interactions between pre-mRNA, guide RNAs (gRNAs), the catalytic RNA editing complex (RECC), and a set of RNA helicases. ...[more]
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