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Cryoelectron microscopy of IL-21/IL-21R/common gamma signaling complex

ABSTRACT:

SUBMITTER: Kevin M Jude

PROVIDER: EMPIAR-11679 | biostudies-other |

REPOSITORIES: biostudies-other

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A structural blueprint for interleukin-21 signal modulation.

Abhiraman Gita C GC Bruun Theodora U J TUJ Caveney Nathanael A NA Su Leon L LL Saxton Robert A RA Yin Qian Q Tang Shaogeng S Davis Mark M MM Jude Kevin M KM Garcia K Christopher KC

Cell reports 20230619 6

Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better understand the structural basis of IL-21 signaling, we determine the structure of the IL-21-IL-21R-γc ternary signaling complex by X-ray crystallography and a structure of a dimer of trimeric complexes using cryo-electron microscopy. Guided by the struct ...[more]

PMID: 37339051

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