Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Taf15, TMEM106B and Aß42 amyloid filaments - Individual 4, frontal cortex

ABSTRACT:

SUBMITTER: Benjamin Ryskeldi-Falcon

PROVIDER: EMPIAR-11739 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Publications

TAF15 amyloid filaments in frontotemporal lobar degeneration.

Tetter Stephan S Arseni Diana D Murzin Alexey G AG Buhidma Yazead Y Peak-Chew Sew Y SY Garringer Holly J HJ Newell Kathy L KL Vidal Ruben R Apostolova Liana G LG Lashley Tammaryn T Ghetti Bernardino B Ryskeldi-Falcon Benjamin B

Nature 20231206 7994

Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer's disease, and is often also associated with motor disorders<sup>1</sup>. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins<sup>2</sup>. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different F ...[more]

PMID: 38057661

Similar Datasets

Taf15 amyloid filaments - Individual 1, frontal cortex

Project description: Not available

| EMPIAR-11735 | biostudies-other

Taf15, TMEM106B and Aß42 amyloid filaments - Individual 4, brainstem

Project description: Not available

| EMPIAR-11740 | biostudies-other

Taf15 amyloid filaments - Individual 1, motor cortex

Project description: Not available

| EMPIAR-11736 | biostudies-other

Taf15 amyloid filaments - Individual 3

Project description: Not available

| EMPIAR-11738 | biostudies-other

Taf15 amyloid filaments - Individual 2

Project description: Not available

| EMPIAR-11737 | biostudies-other

TAF15 amyloid filaments in frontotemporal lobar degeneration.

Project description:Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer's disease, and is often also associated with motor disorders1. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins2. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes3,4. The presence of amyloid filaments and their identities and structures in the remaining approximately 10% of FTLD cases are unknown but are widely believed to be composed of the protein fused in sarcoma (FUS, also known as translocated in liposarcoma). As such, these cases are commonly referred to as FTLD-FUS. Here we used cryogenic electron microscopy (cryo-EM) to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with FTLD-FUS. Surprisingly, we found abundant amyloid filaments of the FUS homologue TATA-binding protein-associated factor 15 (TAF15, also known as TATA-binding protein-associated factor 2N) rather than of FUS itself. The filament fold is formed from residues 7-99 in the low-complexity domain (LCD) of TAF15 and was identical between individuals. Furthermore, we found TAF15 filaments with the same fold in the motor cortex and brainstem of two of the individuals, both showing upper and lower motor neuron pathology. The formation of TAF15 amyloid filaments with a characteristic fold in FTLD establishes TAF15 proteinopathy in neurodegenerative disease. The structure of TAF15 amyloid filaments provides a basis for the development of model systems of neurodegenerative disease, as well as for the design of diagnostic and therapeutic tools targeting TAF15 proteinopathy.

| S-EPMC10781619 | biostudies-literature

TAF15 amyloid filaments in neurodegenerative disease

Project description:Frontotemporal dementia (FTD) is the most common form of dementia after Alzheimer's disease and results from frontotemporal lobar degeneration (FTLD). The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins1. In the majority of cases, the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterising different FTLD subtypes2,3. The presence, identities and structures of amyloid filaments in the remaining ~10% of FTLD cases are unknown, but are widely believed to be composed of the protein fused in sarcoma (FUS). As such, these cases are commonly referred to as FTLD-FUS. Here, we used cryogenic electron microscopy (cryo-EM) to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with FTLD-FUS. Unexpectedly, we found abundant amyloid filaments of the FUS homologue TATA-binding protein-associated factor 15 (TAF15), rather than of FUS itself. The filament fold is formed from residues 7 to 99 in the low-complexity domain (LCD) of TAF15 and was identical between individuals. The formation of TAF15 amyloid filaments with a characteristic fold in FTLD establishes TAF15 proteinopathy in neurodegenerative disease. Furthermore, we found TAF15 filaments with the same fold in the motor cortex and brainstem of two of the individuals, who also showed changes associated with amyotrophic lateral sclerosis (ALS), suggesting that TAF15 proteinopathy may underlie a disease spectrum of FTLD and ALS. The structure of TAF15 amyloid filaments provides a basis for the development of model systems of neurodegenerative disease, as well as for the design of diagnostic and therapeutic tools targeting TAF15 proteinopathy.

2023-12-07 | PXD044821 | Pride

Structure of pathological TDP-43 filaments from ALS with FTLD (Individual 1, frontal cortex)

Project description: Not available

| EMPIAR-10830 | biostudies-other

Structure of pathological TDP-43 filaments from ALS with FTLD (Individual 2, frontal cortex)

Project description: Not available

| EMPIAR-10832 | biostudies-other

Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with Alzheimer’s disease of amyloid-β 42 filaments

Project description: Not available

| EMPIAR-10916 | biostudies-other