Cryo-EM SPA datasets of Streptococcus pneumoniae NADPH oxidase F397A mutant with NADPH under turnover conditions
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ABSTRACT:
SUBMITTER: Bonnie J Murphy
PROVIDER: EMPIAR-11744 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase.
Dubach Victor R A VRA San Segundo-Acosta Pablo P Murphy Bonnie J BJ
Nature structural & molecular biology 20240722 11
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) have a major role in the physiology of eukaryotic cells by mediating reactive oxygen species production. Evolutionarily distant proteins with the NOX catalytic core have been found in bacteria, including Streptococcus pneumoniae NOX (SpNOX), which is proposed as a model for studying NOXs because of its high activity and stability in detergent micelles. We present here cryo-electron microscopy structures of substrate-free and nic ...[more]
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