Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Schmidt
PROVIDER: EMPIAR-11745 | biostudies-other |
REPOSITORIES: biostudies-other
Sharma Kartikay K Stockert Fabian F Shenoy Jayakrishna J Berbon Mélanie M Abdul-Shukkoor Muhammed Bilal MB Habenstein Birgit B Loquet Antoine A Schmidt Matthias M Fändrich Marcus M
Nature communications 20240112 1
The transactive response DNA-binding protein-43 (TDP-43) is a multi-facet protein involved in phase separation, RNA-binding, and alternative splicing. In the context of neurodegenerative diseases, abnormal aggregation of TDP-43 has been linked to amyotrophic lateral sclerosis and frontotemporal lobar degeneration through the aggregation of its C-terminal domain. Here, we report a cryo-electron microscopy (cryo-EM)-based structural characterization of TDP-43 fibrils obtained from the full-length ...[more]