Ontology highlight
ABSTRACT:
SUBMITTER: Basil J Greber
PROVIDER: EMPIAR-11807 | biostudies-other |
REPOSITORIES: biostudies-other
Cushing Victoria I VI Koh Adrian F AF Feng Junjie J Jurgaityte Kaste K Bondke Alexander A Kroll Sebastian H B SHB Barbazanges Marion M Scheiper Bodo B Bahl Ash K AK Barrett Anthony G M AGM Ali Simak S Kotecha Abhay A Greber Basil J BJ
Nature communications 20240313 1
Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallization has been hampered by the often-limiting resolution and throughput of cryogenic electron microscopy (cryo-EM). Here, we use high-resolution cryo-EM to determine structures of the CDK-activating kinase, a master regulator of cell growth and division, in its ...[more]