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Cryo-EM structure of the CAK-CT7030 complex


ABSTRACT:

SUBMITTER: Basil J Greber 

PROVIDER: EMPIAR-11807 | biostudies-other |

REPOSITORIES: biostudies-other

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Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallization has been hampered by the often-limiting resolution and throughput of cryogenic electron microscopy (cryo-EM). Here, we use high-resolution cryo-EM to determine structures of the CDK-activating kinase, a master regulator of cell growth and division, in its  ...[more]

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