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CryoEM micrographs of a group II RNP in the post-ligation state

ABSTRACT:

SUBMITTER: Anna Marie Pyle

PROVIDER: EMPIAR-11809 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural insights into intron catalysis and dynamics during splicing.

Xu Ling L Liu Tianshuo T Chung Kevin K Pyle Anna Marie AM

Nature 20231122 7992

The group II intron ribonucleoprotein is an archetypal splicing system with numerous mechanistic parallels to the spliceosome, including excision of lariat introns<sup>1,2</sup>. Despite the importance of branching in RNA metabolism, structural understanding of this process has remained elusive. Here we present a comprehensive analysis of three single-particle cryogenic electron microscopy structures captured along the splicing pathway. They reveal the network of molecular interactions that spec ...[more]

PMID: 37993708

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