Dataset Information
Cryo-EM of SARS-CoV-2 5' proximal stem-loops 5-6
Ontology highlight
ABSTRACT:
SUBMITTER: Rhiju Das
PROVIDER: EMPIAR-11813 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
Proceedings of the National Academy of Sciences of the United States of America 20240301 10
Coronavirus genomes sequester their start codons within stem-loop 5 (SL5), a structured, 5' genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of SL5 is predicted to contain a four-way junction of helical stems, some of which are capped with UUYYGU hexaloops. Here, using cryogenic electron microscopy (cryo-EM) and computational modeling with biochemically determined secondary structures, we present three-dimensional structures of SL5 from six coronaviruses. The SL ...[more]