Dataset Information
Cryo-EM structure of a non-neutralizing antibody V5-4 in complex with SARS-CoV-2 spike
Ontology highlight
ABSTRACT:
SUBMITTER: Goran Bajic
PROVIDER: EMPIAR-11847 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination.
Cell reports 20241105 11
Neutralizing antibodies correlate with protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent studies, however, show that binding antibody titers, in the absence of robust neutralizing activity, also correlate with protection against disease progression. Non-neutralizing antibodies cannot directly protect against infection but may recruit effector cells and thus contribute to the clearance of infected cells. Additionally, they often bind conserved epitopes across ...[more]