Dataset Information
Single-particle cryo-EM unaligned micrographs of NTD-directed neutralizing antibody 4-18 in complex with prefusion SARS-CoV-2 spike glycoprotein
Ontology highlight
ABSTRACT:
SUBMITTER: Gabriele Cerutti
PROVIDER: EMPIAR-11868 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.
Cell host & microbe 20210312 5
Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. Here, we report cryo-EM and crystal structures for seven potent NTD-directed neutralizing antibodies in complex with spike or isolated NTD. These structures defined several antibody classes, with at lea ...[more]