Dataset Information
Single-particle cryo-EM unaligned micrographs of antibody SKT05 in complex with Western Equine Encephalitis Virus-Like Particles
Ontology highlight
ABSTRACT:
SUBMITTER: Gabriele Cerutti
PROVIDER: EMPIAR-11935 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell 20230608 12
Alphaviruses are RNA viruses that represent emerging public health threats. To identify protective antibodies, we immunized macaques with a mixture of western, eastern, and Venezuelan equine encephalitis virus-like particles (VLPs), a regimen that protects against aerosol challenge with all three viruses. Single- and triple-virus-specific antibodies were isolated, and we identified 21 unique binding groups. Cryo-EM structures revealed that broad VLP binding inversely correlated with sequence and ...[more]