Dataset Information
Cryo-ET tilt series of tetracycline-treated FIB-milled E. coli ED1a cells
Ontology highlight
ABSTRACT:
SUBMITTER: Iskander Khusainov
PROVIDER: EMPIAR-11948 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction.
Nature communications 20240605 1
Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative bacteria are lacking, despite their ribosomes being major antimicrobial drug targets. Here we compare two E. coli strains, a lab E. coli K-12 and human gut isolate E. coli ED1a, for which tetracycline exhibits bacteriostatic and bactericidal act ...[more]