Cryo-EM of Caulobacter crescentus tad pilus
Ontology highlight
ABSTRACT:
SUBMITTER: Ravi Raghavbhai Sonani
PROVIDER: EMPIAR-11982 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Tad and toxin-coregulated pilus structures reveal unexpected diversity in bacterial type IV pili.
Sonani Ravi R RR Sanchez Juan Carlos JC Baumgardt Joseph K JK Kundra Shivani S Wright Elizabeth R ER Craig Lisa L Egelman Edward H EH
Proceedings of the National Academy of Sciences of the United States of America 20231127 49
Type IV pili (T4P) are ubiquitous in both bacteria and archaea. They are polymers of the major pilin protein, which has an extended and protruding N-terminal helix, α1, and a globular C-terminal domain. Cryo-EM structures have revealed key differences between the bacterial and archaeal T4P in their C-terminal domain structure and in the packing and continuity of α1. This segment forms a continuous α-helix in archaeal T4P but is partially melted in all published bacterial T4P structures due to a ...[more]
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