Structure of an ALYREF-exon junction complex hexamer
Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Kopano Vorländer
PROVIDER: EMPIAR-12036 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
mRNA recognition and packaging by the human transcription-export complex.
Pacheco-Fiallos Belén B Vorländer Matthias K MK Riabov-Bassat Daria D Fin Laura L O'Reilly Francis J FJ Ayala Farja I FI Schellhaas Ulla U Rappsilber Juri J Plaschka Clemens C
Nature 20230405 7958
Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes (mRNPs) and are recognized by the essential transcription-export complex (TREX) for nuclear export<sup>1,2</sup>. However, the mechanisms of mRNP recognition and three-dimensional mRNP organization are poorly understood<sup>3</sup>. Here we report cryo-electron microscopy and tomography structures of reconstituted and endogenous human mRNPs bound to the 2-MDa TREX complex. We show that mRNPs are recognized throug ...[more]
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