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In situ cryoET of beta-amyloid and tau in post-mortem Alzheimer's disease brain


ABSTRACT:

SUBMITTER: Rene Frank 

PROVIDER: EMPIAR-12092 | biostudies-other |

REPOSITORIES: biostudies-other

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A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures<sup>1</sup>. In Alzheimer's disease, this is characterized by the deposition of β-amyloid and tau with disease-specific conformations. The in situ structure of amyloid in the human brain is unknown. Here, using cryo-fluorescence microscopy-targeted cryo-sectioning, cryo-focused ion beam-scanning electron microscopy lift-out and cryo-electron tomography  ...[more]

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