Cryo electron microscopy unaligned movie frames for single particle analysis of the Escherichia coli 70S ribosome with Myxovalargin A
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ABSTRACT:
SUBMITTER: Timm Oliver Koller
PROVIDER: EMPIAR-12111 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
Koller Timm O TO Scheid Ullrich U Kösel Teresa T Herrmann Jennifer J Krug Daniel D Boshoff Helena I M HIM Beckert Bertrand B Evans Joanna C JC Schlemmer Jan J Sloan Becky B Weiner Danielle M DM Via Laura E LE Moosa Atica A Ioerger Thomas R TR Graf Michael M Zinshteyn Boris B Abdelshahid Maha M Nguyen Fabian F Arenz Stefan S Gille Franziska F Siebke Maik M Seedorf Tim T Plettenburg Oliver O Green Rachel R Warnke Anna-Luisa AL Ullrich Joachim J Warrass Ralf R Barry Clifton E CE Warner Digby F DF Mizrahi Valerie V Kirschning Andreas A Wilson Daniel N DN Müller Rolf R
Journal of the American Chemical Society 20230105 2
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against <i>Mycobacterium tuberculosis</i>. To ensure compound supply for further development, we studied myxovalargin biosynthesis in detail enabling production via fermentation of a native producer. Feeding experiments as well as func ...[more]
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