Ontology highlight
ABSTRACT:
SUBMITTER: Huilin Li
PROVIDER: EMPIAR-12126 | biostudies-other |
REPOSITORIES: biostudies-other
He Qing Q Wang Feng F O'Donnell Michael E ME Li Huilin H
Proceedings of the National Academy of Sciences of the United States of America 20240426 18
The DNA sliding clamp PCNA is a multipurpose platform for DNA polymerases and many other proteins involved in DNA metabolism. The topologically closed PCNA ring needs to be cracked open and loaded onto DNA by a clamp loader, e.g., the well-studied pentameric ATPase complex RFC (RFC1-5). The CTF18-RFC complex is an alternative clamp loader found recently to bind the leading strand DNA polymerase ε and load PCNA onto leading strand DNA, but its structure and the loading mechanism have been unknown ...[more]