Ontology highlight
ABSTRACT:
SUBMITTER: Kenneth Taylor
PROVIDER: EMPIAR-12141 | biostudies-other |
REPOSITORIES: biostudies-other
Chen Liang L Liu Jun J Rastegarpouyani Hosna H Janssen Paul M L PML Pinto Jose R JR Taylor Kenneth A KA
Proceedings of the National Academy of Sciences of the United States of America 20240222 9
Heart muscle has the unique property that it can never rest; all cardiomyocytes contract with each heartbeat which requires a complex control mechanism to regulate cardiac output to physiological requirements. Changes in calcium concentration regulate the thin filament activation. A separate but linked mechanism regulates the thick filament activation, which frees sufficient myosin heads to bind the thin filament, thereby producing the required force. Thick filaments contain additional nonmyosin ...[more]