The Prothrombin-Prothrombinase Interaction
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ABSTRACT:
SUBMITTER: Enrico Di Cera
PROVIDER: EMPIAR-12201 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The Prothrombin-Prothrombinase Interaction.
Stojanovski Bosko M BM Mohammed Bassem M BM Di Cera Enrico E
Sub-cellular biochemistry 20240101
The hemostatic response to vascular injury entails a sequence of proteolytic events where several inactive zymogens of the trypsin family are converted to active proteases. The cascade starts with exposure of tissue factor from the damaged endothelium and culminates with conversion of prothrombin to thrombin in a reaction catalyzed by the prothrombinase complex composed of the enzyme factor Xa, cofactor Va, Ca<sup>2+</sup>, and phospholipids. This cofactor-dependent activation is paradigmatic of ...[more]
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Project description: Not available
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