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Cryo-EM Micrographs of Amyloid Fibrils of Mixed 0N4R and 0N3R Tau Seeded with Alzheimer's Disease Tau from Human Brain

ABSTRACT:

SUBMITTER: Aurelio James Dregni

PROVIDER: EMPIAR-12306 | biostudies-other |

REPOSITORIES: biostudies-other

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Alzheimer's disease seeded tau forms paired helical filaments yet lacks seeding potential.

Duan Pu P Dregni Aurelio J AJ Xu Hong H Changolkar Lakshmi L Lee Virginia M-Y VM Lee Edward B EB Hong Mei M

The Journal of biological chemistry 20240828 9

Alzheimer's disease (AD) and many other neurodegenerative diseases are characterized by pathological aggregation of the protein tau. These tau aggregates spread in a stereotypical spatiotemporal pattern in the brain of each disease, suggesting that the misfolded tau can recruit soluble monomers to adopt the same pathological structure. To investigate whether recruited tau indeed adopts the same structure and properties as the original seed, here we template recombinant full-length 0N3R tau, 0N4R ...[more]

PMID: 39214304

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