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Gelsolin-severed and capped F-actin raw data from 'Mechanism of actin filament severing and capping by gelsolin'

ABSTRACT:

SUBMITTER: Roberto Dominguez

PROVIDER: EMPIAR-12405 | biostudies-other |

REPOSITORIES: biostudies-other

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Mechanism of actin filament severing and capping by gelsolin.

Barrie Kyle R KR Rebowski Grzegorz G Dominguez Roberto R

Nature structural & molecular biology 20241024

Gelsolin is the prototypical member of a family of Ca<sup>2+</sup>-activated F-actin severing and capping proteins. Here we report structures of Ca<sup>2+</sup>-bound human gelsolin at the barbed end of F-actin. One structure reveals gelsolin's six domains (G1G6) and interdomain linkers wrapping around F-actin, while another shows domains G1G3-a fragment observed during apoptosis-binding on both sides of F-actin. Conformational changes that trigger severing occur on one side of F-actin with G1G6 ...[more]

PMID: 39448849

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