Cryo electron microscopy of Medusavirus medusae nucleosome-like particle
Ontology highlight
ABSTRACT:
SUBMITTER: Karolin Luger
PROVIDER: EMPIAR-12445 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone.
Toner Chelsea M CM Hoitsma Nicole M NM Weerawarana Sashi S Luger Karolin K
Nature communications 20241023 1
The organization of DNA into nucleosomes is a ubiquitous and ancestral feature that was once thought to be exclusive to the eukaryotic domain of life. Intriguingly, several representatives of the Nucleocytoplasmic Large DNA Viruses (NCLDV) encode histone-like proteins that in Melbournevirus were shown to form nucleosome-like particles. Medusavirus medusae (MM), a distantly related giant virus, encodes all four core histone proteins and, unique amongst most giant viruses, a putative acidic protei ...[more]
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