Morphine-induced microbial dysbiosis disrupts IgA-bacterial homeostasis

ABSTRACT: Background: Morphine is commonly prescribed to manage moderate to severe pain despite many intestinal side effects including modulation of the immune system, rapid induction of intestinal microbial dysbiosis, and disruption of gut epithelial barrier. Morphine-induced microbial dysbiosis is characterized by decreased relative abundance of commensal bacteria with a corresponding increase in potentially pathogenic bacteria. Immunoglobulin A (IgA) dictates the composition of the intestinal microbiome. Morphine use results in microbial dysbiosis within 24 hours and presents a unique opportunity to observe IgA responses in the initial period of microbial dysbiosis. Methods: Here, we use a mouse model of chronic morphine-induced dysbiosis to gain insight on the function of IgA during the f

ORGANISM(S): mouse gut metagenome

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PROVIDER: S-BSST1193 | biostudies-other |

REPOSITORIES: biostudies-other