Hydrogen decreases susceptibility to Ang II-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways

ABSTRACT: Atrial fibrillation (AF) represents the commonly occurring cardiac arrhythmia and the main factor leading to stroke and heart failure. Hydrogen (H2) is a gaseous signaling molecule that has the effects of anti-inflammation and antioxidation. Our study provides evidence that hydrogen decreases susceptibility to Ang II-mediated AF together with atrial fibrosis. Following continuous Ang II administration for a 28-day period, AngII+H2 treated rats showed decreased susceptibility to AF, a decrease in atrial fibrosis, a decrease in ROS in atrial myocytes, an inhibition of NLRP3 inflammasome activation, an improvement in electrical remodeling, and an inhibition of proliferation and migration of cardiac fibroblasts. We further found that hydrogen regulates the activation of inflammasome and thus i

ORGANISM(S): Rattus norvegicus (brown rat)

SUBMITTER:  

PROVIDER: S-BSST1243 | biostudies-other |

SECONDARY ACCESSION(S): 1

REPOSITORIES: biostudies-other