Data for: Small RNAs as biomarkers to differentiate benign and malign prostate diseases: an alternative for transrectal punch biopsy of the prostate?

ABSTRACT: It was investigated whether urinary miRNAs can be used as biomarkers to differentiate the prostate diseases above. Therefore urine samples from urological patients with BPH (25) or PCa (28) were analysed using Next-Generation Sequencing to detect the expression profile of total and exosomal miRNA/piRNA. 79 miRNAs and 5 piwi-interacting RNAs (piRNAs) were significantly differentially expressed (adjusted p-value < 0.05 and log2-Fc > 1 or < -1). Of these, 6 miRNAs and 2 piRNAs could be statistically validated (AUC on test cohort >= 0.7). In addition, machine-learning algorithms were used to identify a panel of 22 additional miRNAs, whose interaction makes it possible to differentiate the groups as well. I hereby publish all relevant data for the full traceability of the study.

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Lukas Markert 

PROVIDER: S-BSST586 | biostudies-other |

REPOSITORIES: biostudies-other